HIGHLIGHTED TOPIC Role of Inflammation in Skeletal Muscle, Connective Tissue, and Exertional Injuries: To Block or Not to Block? MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix
نویسندگان
چکیده
Max E. Davis, Jonathan P. Gumucio, Kristoffer B. Sugg, Asheesh Bedi, and Christopher L. Mendias Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; and Department of Surgery, Section of Plastic Surgery, University of Michigan Medical School, Ann Arbor, Michigan
منابع مشابه
HIGHLIGHTED TOPIC Role of Inflammation in Skeletal Muscle, Connective Tissue, and Exertional Injuries: To Block or Not to Block? NSAID therapy effects on healing of bone, tendon, and the enthesis
Su B, O’Connor JP. NSAID therapy effects on healing of bone, tendon, and the enthesis. J Appl Physiol 115: 892–899, 2013. First published July 18, 2013; doi:10.1152/japplphysiol.00053.2013.—Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established. However, the effects of NSAI...
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INFLAMMATION HAS BEEN DESCRIBED as part of the healing process since Hippocrates in ancient Greece (5). Inflammatory responses are initiated immediately after tissue damage to protect the organism, but a hyperactive inflammatory response may attack healthy tissues. In such situations, anti-inflammatory therapies are warranted, and physically active populations (e.g., athletes and soldiers) ofte...
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Kjaer M, Bayer ML, Eliasson P, Heinemeier KM. What is the impact of inflammation on the critical interplay between mechanical signaling and biochemical changes in tendon matrix? J Appl Physiol 115: 879–883, 2013. First published April 25, 2013; doi:10.1152/japplphysiol.00120.2013.—Mechanical loading can influence tendon collagen homeostasis in animal models, while the dynamics of the human adul...
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Mackey AL. Does an NSAID a day keep satellite cells at bay? J Appl Physiol 115: 900–908, 2013. First published May 16, 2013; doi:10.1152/japplphysiol.00044.2013.— Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely consumed by athletes worldwide, despite growing evidence for a negative influence on the adaptation of skeletal muscle to exercise, at least in young healthy individuals. This r...
متن کاملHIGHLIGHTED TOPIC Role of Inflammation in Skeletal Muscle, Connective Tissue, and Exertional Injuries: To Block or Not to Block? Anti-inflammatory interventions and skeletal muscle injury: benefit or detriment?
Urso ML. Anti-inflammatory interventions and skeletal muscle injury: benefit or detriment? J Appl Physiol 115: 920–928, 2013. First published March 28, 2013; doi:10.1152/japplphysiol.00036.2013.—Exercise, eccentric contractions, acute trauma, and disease are all causal mechanisms of skeletal muscle injury. After skeletal muscle is injured, it undergoes sequential phases of degeneration, inflamm...
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تاریخ انتشار 2013